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KMID : 0043320100330111843
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Archives of Pharmacal Research
2010 Volume.33 No. 11 p.1843 ~ p.1850
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Anti-inflammatory effect of visnagin in lipopolysaccharide-stimulated BV-2 microglial cells
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Lee Jin-Koo
Jung Jun-Sub
Park Sang-Hee
Park Soo-Hyun
Sim Yun-Beom
Kim Seon-Mi
Ha Tal-Soo
Suh Hong-Won
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Abstract
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Visnagin, which is found in Ammi visnaga, has biological activity as a vasodilator and reduces blood pressure by inhibiting calcium influx into the cell. The present study demonstrates the anti-inflammatory effect of visnagin on lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. When cells were treated with visnagin prior to LPS stimulation, production of nitric oxide and expression of iNOS were attenuated in a dose-dependent manner. Visnagin also caused a significant decrease of mRNA expression and release of TNF-α, IL-1β and IFNγ. In addition, visnagin reduced LPS-induced IL-6 and MCP-1 mRNA level. We further found that visnagin dose-dependently inhibited LPS-induced AP-1 and NF-κB luciferase activities. Taken together, our results for the first time suggest that the anti-inflammatory effect of visnagin might result from the inhibition of transcription factors, such as AP-1 and NF-κB.
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KEYWORD
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Anti-inflammation, Microglial cells, Visnagin, Inducible nitric oxide synthase, AP-1, NF-κB
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